American Association of Critical-Care Nurses (AACN) Certification Practice Test

In cases of C. difficile infection, what is there controversy regarding?

1. The use of intravenous vancomycin

2. The use of probiotics

3. The necessity of hospitalization

4. The duration of antibiotic therapy

The correct answer is: The use of probiotics

The controversy surrounding the use of probiotics in cases of Clostridioides difficile infection (CDI) stems from the mixed evidence regarding their efficacy and safety in preventing or treating CDI. While some studies suggest that probiotics may help restore the gut microbiota and reduce the recurrence of CDI, others indicate that there's insufficient or inconclusive evidence to support their routine use. Moreover, there are concerns about potential side effects, particularly in certain vulnerable populations, such as those who are immunocompromised or have severe underlying health conditions. As a result, standard clinical guidelines may not uniformly recommend probiotics for CDI management, leaving health care providers to weigh the potential benefits against the risks on a case-by-case basis. This presents an ongoing debate in clinical practice about whether or not their incorporation into treatment strategies is warranted, highlighting the need for further research to establish clear guidelines. The other options present more straightforward practices in managing CDI, where the evidence and recommendations from health authorities are more definitive.