American Association of Critical-Care Nurses (AACN) Certification Practice Test

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What are ARBs known to increase alongside lowering blood pressure?

Heart rate
Cardiac output
Cholesterol levels
Fluid retention

The correct answer is: Cardiac output

Angiotensin II receptor blockers (ARBs) are primarily used to lower blood pressure by blocking the effects of angiotensin II, a hormone that constricts blood vessels and raises blood pressure. Alongside this blood pressure-lowering effect, ARBs can also have an impact on cardiac output. When blood pressure decreases, it may allow for improved blood flow and reduced vascular resistance, which can lead to changes in how the heart operates. In certain instances, this improved efficiency can result in an increase in cardiac output. This is particularly relevant in patients who may have heart conditions where improving cardiac output is beneficial. While it's essential to consider that the effects can vary among different individuals and clinical scenarios, the primary function of ARBs in relation to cardiac output is tied to their mechanism of reducing systemic vascular resistance and improving the hemodynamic state of the heart.