American Association of Critical-Care Nurses (AACN) Certification Practice Test

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What deficiency is associated with Hemophilia A?

  1. Factor IX

  2. Factor VII

  3. Factor VIII

  4. Factor X

The correct answer is: Factor VIII

Hemophilia A is specifically characterized by a deficiency in Factor VIII, which is a crucial protein required for blood clotting. This condition is inherited in an X-linked recessive manner, meaning that it predominantly affects males, as they have only one X chromosome. In individuals with Hemophilia A, the lack of Factor VIII leads to prolonged bleeding after injuries, increased susceptibility to bruising, and spontaneous bleeding episodes, particularly into joints and muscles. Understanding the role of Factor VIII in the coagulation cascade is essential, as its deficiency directly impacts the individual's ability to form stable blood clots. This knowledge helps in managing the condition, including the administration of recombinant Factor VIII or fresh frozen plasma to control bleeding episodes and improve the patient's quality of life.

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