American Association of Critical-Care Nurses (AACN) Certification Practice Test

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What is the reversal agent for dabigatran?

Idarucizumab (Praxbind)
Aspirin
Warfarin
Enoxaparin

The correct answer is: Idarucizumab (Praxbind)

Idarucizumab, marketed under the brand name Praxbind, is the specific reversal agent for dabigatran, which is a direct oral anticoagulant used to prevent and treat thromboembolic events. Dabigatran works by inhibiting thrombin, an enzyme critical for the coagulation process. In cases where rapid reversal of anticoagulation is necessary, particularly in scenarios such as major bleeding or urgent surgery, idarucizumab binds to dabigatran and neutralizes its effect almost instantaneously. This mechanism allows for a controlled restoration of hemostasis. The other agents listed do not serve the same purpose in reversing dabigatran’s effects. Aspirin is an antiplatelet medication that prevents platelet aggregation and is not designed to reverse the anticoagulation effects of dabigatran. Warfarin is an older anticoagulant that works through a different mechanism and is reversed with vitamin K, not effective for dabigatran. Enoxaparin is a low-molecular-weight heparin used for anticoagulation but does not reverse dabigatran either. Therefore, idarucizumab is the correct and specific agent for reversing the effects of dabigatran, making it